CEFTIONIX

CEFTIONIX® Injection

For Veterinary Use Only

Composition

Each ml contains:

• Ceftiofur (as ceftiofur sodium or hydrochloride) …… 50 mg

• Excipients ……………………………………………………………… q.s. to 1 ml

(Standard concentration for 100-ml ceftiofur injectable products)

Pharmacological Class

Third-generation cephalosporin antibiotic (β-lactam)

Indications

CEFTIONIX® Injection is indicated for the treatment of bacterial infections caused by ceftiofur-sensitive organisms in animals, including:

Cattle

• Bovine Respiratory Disease (BRD) caused by
  Mannheimia haemolytica, Pasteurella multocida, Histophilus somni

• Acute interdigital necrobacillosis (foot rot)

• Acute postpartum metritis

• Acute mastitis caused by E. coli

Swine

• Respiratory disease caused by Actinobacillus pleuropneumoniae, Pasteurella multocida

• Septicemia and polyserositis

Ceftiofur provides broad-spectrum bactericidal activity against Gram-positive and Gram-negative pathogens and is stable against β-lactamase enzymes.

Dosage and Administration

Routes:

• Intramuscular (IM)

• Subcutaneous (SC)

Recommended dosage:

Cattle

• 1 mg ceftiofur/kg body weight
  (Equivalent to 1 ml per 50 kg BW)

• Once daily for 3–5 days

Swine

• 3 mg ceftiofur/kg body weight
  (Equivalent to 1 ml per 16–17 kg BW)

• Once daily for 3 days

Inject into the neck region only.
Do not exceed 10 ml per injection site.

Target Species

Cattle and swine

Contraindications

• Hypersensitivity to ceftiofur, cephalosporins, or other β-lactam antibiotics

• Do not use in animals with known severe allergic reactions to β-lactams

• Not intended for use in poultry

Precautions

• For veterinary use only

• Use under veterinary supervision

• Do not administer intravenously

• Observe aseptic injection technique

• Avoid accidental self-injection

• Do not mix with other injectable products in the same syringe

• Keep out of reach of children

Withdrawal Period

(Subject to national regulatory approval)

Cattle

• Meat: Typically 3–4 days

• Milk: 0 hours (often nil withdrawal)

Swine

• Meat: Typically 3–5 days

(Always confirm exact withdrawal periods according to local regulations and formulation type)

Storage

• Store below 25°C

• Protect from light

• Do not freeze

• Keep container tightly closed

• Use within recommended period after first broaching

Presentation

• 100 ml multidose vial